• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention provides a process for the production of reagent solutions containing a plurality of components for analytical purposes, wherein the individual components of several differently composed reagents are each introduced into a solid, proportionable carrier material in easily redissolvable form in such an amount that each part by volume or weight of the carrier material carries a definite amount of one reagent component, the carriers of the components are brought together in a magazine-like manner and, for the production of a particular reagent, from all carriers which carry a component of the reagent, there are simultaneously taken off the amounts corresponding to the required amounts of the components, which are then dissolved to form the reagent solution. Apparatus for carrying out the process is also provided.
    公开号:SU1286117A3
    申请号:SU792850254
    申请日:1979-12-06
    公开日:1987-01-23
    发明作者:Хаген Александер；Эдельманн Херманн；Клозе Зигмар
    申请人:Берингер Маннхайм Гмбх (Фирма)；
    IPC主号:
    专利说明:

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    The invention relates to devices for the preparation of reagent solutions, which contain a large number of components, and can be used in laboratory practice.
    The purpose of the invention is to improve the accuracy and speed up the preparation of solutions from several components.
    Figure 1 shows schematically a device, a general view; Figure 2 shows a carrier cassette, a vertical section; fig.Z - the same, general view in axonometric projection; 4 is a tank for a solvent, a general view in axonometric projection; on fig.Z - the device of a projection, the second option; Figure 6 shows a cassette with a carrier material, cross-section.
    The device includes a transporting device, a cassette 2 with carriers 3 placed in front of the transporting device 1, a dispenser A, a control device 5 and a container 6 for the solvent installed after the transporting device 1. The dispenser 4 is located between the cassette 2 and the transporting device 1, with This control unit 5 is connected to the dispenser. The carriers 3 are made in the form of rolled sheets 7, and the dispenser 4 is equipped with a sliding device 8 located opposite the holes 9 for outputting the tray 7 of the carrier 3 made in the side wall of the cassette 2, and with the cutting tools 10 secured to the sliding device 8 for cutting pieces of web 7 of carriers 3 exiting through the opening 9 of cassette 2.
    The cassette 2 is provided with movable trays 11 in which the webs 7 of the carrier 3 are placed. The transport device 1 is made in the form of a transfer belt 12 for transferring individual parts of the carrier 3 from the cassette 2. to the solvent container 6. The transport device 1 is provided with a pneumatic tube 13 and a blower 14 housed in it. The pre-tube 13 is connected to the side wall of the cassette 2, the holes 9 in which to take out the blade 7 of the carrier 3 enter the pneumatic sleeve 13.
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    Retractable device 8 is equipped with a gear 15, which engages with its teeth with perforation, made in the blade 7 of the carrier 3. The dispenser is equipped with a cutting tool 16 for cutting out the carrier web 3 of a specified number of segments of the same size.
    The capacity of 6 dp of solvent is made in the form of a cuvette 17 of optically transparent material, which is equipped with a rod-shaped latch 18, made with the possibility of movement in the vertical direction, and a perforated sieve piston 19, fixed on the lower end of the latch 18.
    The cassette 2 contains a carrier material 3 in the form of a paper roll, the ends of which protrude from the cassette and from which certain segments are measured and cut off using a dispenser 4. The cut paper strips fall onto the transport device 1, by which the carrier sections are transferred to the container 6 for solvent j where the individual components are dissolved to form the finished reagent solution. When the device 5 is operated with control 20 of choice, controlling the 4 .. metering device, the quantities of carrier material required for each desired reagent composition are measured and separated. The control device 5, the flow meter 21, supplies the solvent to the tank 6,
    The cassette 2 -contains in the housing 22 a plurality of carrier materials arranged next to each other in the form of a paper web 23, which is located in each of the cassette-trays 11. Trays can be individually removed from the cassette and replaced. For each tray 11 in the cassette 2 there is a cassette hole 9 from which a dosing piece can be pulled out and cut off with a dosing device (Fig. 2).
    The dispenser 4 for each roll of paper web 23 is equipped with a stepper motor with bristles 15 controlled by a control device 5, which drives the retractable device 8, namely a pair of rollers, which can also be equipped with transporting teeth. A pair of rolls extends from
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    a certain (in each case) cassette opening 9 a piece of paper web required for preparing a certain amount of the reagent component. With the help of the cutting device 10, which belongs to the dosing device and consists, for example, of a knife, which is arranged parallel to the holes 9, the extended segments of the blade 7 are cut off almost simultaneously. The cassette holes 9 exit into the pneumatic tube 13 connected to the cassette case 22, which contains a blower 14, which draws air from above and squeezes it through the tube 13 downwards. At the other end of the pipe 13, a sieve transporting belt 12 is located, which connects to the container 6 for the solvent. The pipe 13 of the blower 14 and the conveyor belt 12 together form the transport adaptation 1, which introduces segments of the booming web into the solvent contained in the 6 dd1 container of the solvent. In this case the pipe 13 is connected to the cassette case 22 so that the cassette holes 9 are in the wall of the pipe 13 (fig.Z).
    The solvent container 6 is (FIG. 4 consists of a cuvette 17, the side walls of which are made of an optically transparent material such as quartz glass, a polymeric material, and the like, and therefore can be used for optical measurements in solution. The cuvette 17 can be inserted into an appropriate holder for a cuvette of a measuring device, for example a photometer, if the prepared reagent solution serves to conduct separate determinations.
    The cuvette 17 may be part of the AV. analyzer and is positioned in such a way that after adding the sample to be determined, optical changes are made directly without further movement of the cuvette 17.
    In order to obtain the desired transparency for optical measurements, a height-adjustable fixture 18 located in the row of the cuvette 17 is designed in a sieve shape, which carries a perforated sieve piston 19 at its lower end. This rim 19 enters after the feeding of the length 24 of the web 7 on top
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    in the cuvette 17 and installed in such a way that the passage of the segment 24 of the blade 7 around its outer edge in a circle is excluded.
    By moving the piston 19 down, the segments 24 of the blade 7 are removed from the path of the light and do not interfere with the optical measurements. At the same time, the reagent and the sample are mixed down.
    The measuring device 25 is placed in an automatic analyzer.
    Control device 5 can be of any design that allows for appropriately dosing the necessary components for each desired reagent. The electronic control of the device controls the dispenser 4, supplying the necessary quantities of individual carriers. For this purpose (Fig. 3), the individual stepping motors only re-start until the segment 24 of the blade 7 advances to the required length, after which it is cut off.
    Instead of the cutting device 10, a knockout device can be used that is configured to cut out a large, but variable number of pieces of the same size from the carrier web. Such knock-out devices are used, for example, in telegraph devices to obtain perforated strips and can cut up to 250 pieces per second from the web or cut out of it if the coating is a point-like or impregnated. Due to the very large number of sections that can be produced per unit of time, a very nominal unit amount of the reagent component defined in this case is obtained, so that the composition of the reagent solutions can be varied by the finest fractionation.
    If the carrier material consists of solid particles, for example, powder, granules, beads, etc. then, measuring devices such as volume or weight meters are used. In suitable measuring devices based on volumetric measurements, measuring chambers with measuring dimensions are used.
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     Figure 5 shows the construction of a measuring chamber 26 varying in volume, the volume of which is varied by a piston 27 driven by an electric motor with a linearly moving rotor 28. The measuring chamber 26, through a funnel 29 from a measuring device 30, receives a solid carrier material can be cut.
    At the exit of the measuring device 30, the first valve 31 is located, at the entrance to the measuring chamber 26 - the second valve 32 and at the exit from the measuring chamber - the third valve 33. Along with the volume determination, the piston 27 can also perform the function of displacing the carrier material measuring chamber 26.
    The moving parts are controlled by the device 34, which is switched on before the control 35 of choice
    The carrier material flows from the measuring chamber 26 to the transport device 1, which feeds the material to the solvent container 6. Several measuring chambers may be adjacent to the transport device.
    A control device, such as an electronic control, must regulate the advance of the carrier web or control the amount of carrier material that is taken from each part of the cassette. In addition, it can also activate the cutting device, adjust the amount of solvent that is fed to the 6 dp solvent tank, transfer rate if mechanical transport means are used to transfer the measured carrier fractions to the solvent, and the like.
    Entry into electronic control can be carried out by known methods, conventional for controlling all devices of this type, by example using keys, punched tapes, coded cards, etc.
    Suitable carriers for single quantities are, for example, particles of a polymeric material, precious metal, stainless steel, porous glass, porous ceramics, and the like. For the preparation of four reagents using the proposed device (Figures 1 and 3), nine trays are inserted into the cassette 2.
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    1 1. Each cassette contains a paper roll, on which there is one of the necessary components.
    To prepare the reagent, the corresponding punch card is inserted into the control device. The device 5 controls the dispenser 4 in such a way that from the cassettes that contain paper strips with the components, a length segment corresponding in each case to the required amount of substance is pushed into the tube 13 and then simultaneously cut off.
    The paper pieces are blown into the solvent tank 6 by an air stream created by the blower 14, where within 1-2 seconds the individual reagents are removed from the carrier and a ready reagent solution is obtained.
    Three other reagent solutions are prepared in a similar manner.
    The cassette and paper web designs allow simple insertion into the cassette. The movement of the beginning of the web into the cutting device is carried out automatically; therefore, already the first new piece of paper gives the correct quantitative separation into parts. For this, the canvas is filled along its entire length with a dashed increment scale, and the printing ink is chosen in such a way that due to H: it does not cause any adverse chemical effects. Instead, a double row of perforations is used, which are connected, displaced relative to each other, in the direction of the length of the web.
    The cassettes are provided with a transport lock, which is released only by inserting trays 11 into the cassette. It can be used to fix the beginning of the paper web after the clean section on the manufacturing enterprise in a certain and protected place inside tray I. With the help of an optical element of contacting the device in a cassette using electronic control, after inserting the trays, the set length along the web is transported from the trays so that the beginning of the blade exactly fits the cutting device. After the cassette is ready for operation again, the function of contacting the printed scale increment begins
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    act to separate the part. At the same time, the minimum unit quantity is not limited by the scale blocking, since several pulse sensors are used so as to become controllable with respect to the troughs and, thus, to the cutting device. The trays are locked in the cassette with the help of the corresponding guides in a certain (reproducible) place.
    The advantage of the proposed design with the use of incremental scale is that even slight slippage during transportation does not lead to an error when splitting into parts. In addition, the increment control allows you to recognize the end of the web, stop the cassette and, when indicating which cassette is in question, indicate the need to replace it.
    Tray II (Fig. 6), which can be made by injection molding, is provided with a holder 36 for a pretensioned spring transport lock 37, guide webs behind the optical scanning (contacting) device 38 and axle pin 39 for the pressure plate 40, as well as with its screen 41 against the roller for the paper web 42, which can be inserted into the injection tool. Scan
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    The driver 38 and the spring-pressed transfer disk 40 are fixed in the cassette case itself. If the presser disc is excluded, then the guiding blades and the transport locking latch go directly into each other.
    Invention Formula
    1. A device for preparing reagent solutions, including a cassette, movable trays, placed in a cassette, carriers with reagents, placed in trays, a device for moving the media, a capacity for the solvent, and a control device, which are sequentially installed after the cartridge, that, in order to increase the accuracy and speed up the preparation of solutions from several components, it is equipped with a cutting device located between the cassette, a device for moving the carriers, pneumatically Coy pipe - connected with the side wall after the cutter cassette, and a supercharger placed in the pipe.
    2. Device according to Claim 1, characterized in that. The device for transferring the carriers is made in the form of an endless conveyor belt.
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    权利要求:
    Claims (2)
    [1]
    Claim
    1. A device for preparing reagent solutions, including a cassette, movable trays placed in a cassette, reagent carriers placed in the trays, a device for moving carriers, sequentially installed after the cassette, a solvent container and a control device that differs the fact that, in order to improve the accuracy and speed up the preparation of solutions of several components, it is equipped with a cutting device located between the cartridge, a device for moving carriers, pneumatically pipe, - connected to the side wall of the cartridge after the cutting device, and a supercharger placed in the pipe.
    [2]
    2. The device according to claim 1, characterized in that., The device for moving media is made in the form of an endless. Conveyor belt.
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    类似技术:
    公开号 | 公开日 | 专利标题
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    US4488810A|1984-12-18|Chemical analyzer
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    US4311394A|1982-01-19|Automatic analytical apparatus
    SU1286117A3|1987-01-23|Device for preparing solutions of reagents
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    US4826659A|1989-05-02|Apparatus for feed-in and ejection of chemical analysis slide
    DE3134005C2|1985-11-14|Analyzer
    EP0169887B1|1990-06-27|Clinical analysis systems and methods
    DE2749071C2|1984-09-13|Reaction vessel carrier for a device for the automatic photometric analysis of liquid samples
    US3909201A|1975-09-30|Analysis apparatus
    DE3908123C2|1991-07-11|
    DE3315045A1|1984-10-31|Multichannel analyser
    EP0683395A2|1995-11-22|Method and apparatus for analyzing heterogeneous liquids, particularly for counting somatic cells in milk
    同族专利:
    公开号 | 公开日
    DE2852994B1|1980-05-22|
    DE2852994C2|1981-02-05|
    CA1129318A|1982-08-10|
    AT378063B|1985-06-10|
    GB2039039B|1983-05-11|
    GB2039039A|1980-07-30|
    JPS5580053A|1980-06-16|
    US4279991A|1981-07-21|
    FR2443677B1|1984-10-19|
    ATA679979A|1984-10-15|
    CH642176A5|1984-03-30|
    FR2443677A1|1980-07-04|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3324753A|1965-03-04|1967-06-13|Eric S Lindau|Cutter apparatus|
    US3483780A|1967-07-19|1969-12-16|Nypel Inc|Cutter|
    US3554700A|1968-05-06|1971-01-12|Scientific Industries|Method for obtaining a known volume of liquid and absorption apparatus therefor|
    CH583422A5|1972-01-25|1976-12-31|Hoffmann La Roche|
    GB1358511A|1972-05-05|1974-07-03|Geomet|Apparatus for quantitating enzyme activity|
    DE2435302B2|1974-07-23|1976-12-02|Emvo Diagnostica Pharmazeutische Erzeugnisse GmbH & CoKG, 6924 Neckarbischof sheim|REAGENT FOR DETERMINING LIP PROTEINS IN BODY FLUIDS|
    JPS5742537B2|1976-07-05|1982-09-09|
    US4170910A|1977-05-09|1979-10-16|Potomac Applied Mechanics, Inc.|Angle iron cutting|SE8305704D0|1983-10-18|1983-10-18|Leo Ab|Cuvette|
    US5004582A|1987-07-15|1991-04-02|Fuji Photo Film Co., Ltd.|Biochemical analysis apparatus|
    US4941808A|1988-06-29|1990-07-17|Humayun Qureshi|Multi-mode differential fluid displacement pump|
    US6793387B1|1999-05-08|2004-09-21|Chata Biosystems, Inc.|Apparatus for automatic preparation of a mixture and method|
    US6805015B1|2003-05-22|2004-10-19|H. Donald Schwartz|Dual resolution syringe|
    US7185551B2|2003-05-22|2007-03-06|Schwartz H Donald|Pipetting module|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE2852994A|DE2852994C2|1978-12-07|1978-12-07|Device for the preparation of reagent solutions|
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